Components of the PANBioRa biomaterial risk assessment system
ANTIBODY TESTING
Patient-specific interactions between biomaterials and the immune system will be assessed using the ground-breaking Mimotope Variation Analysis technology.
BIOMATERIAL TESTING
Biochemical responses of cells to the presence of biomaterials will be monitored in real time and by integrated biosensors. In addition, PANBioRA includes cytotoxicity and genotoxicity tests with microscopic real-time monitoring capacities
CELL TESTING
Real-time electrochemical sensing will be used to determine the cellular response to a given biomaterial. A set of cytokines released to the extracellular environment will be used as biomarkers to assess the cell response to different biomaterials.
ORGAN ON A CHIP
Respiratory epithelium, gut and liver tissues will be miniaturized into organoids on chip to allow the determination of possible systemic and target organ-specific effects in both healthy and disease conditions.
SIMULATIONS
Potential risks that are difficult to assess experimentally – such as explosion hazards or full-scale biomaterial/microbiota interactions - will be covered by simulations developed within the project.
DATA ANALYSIS
The readouts of the modules will be fed into a model developed within PANBioRA using known biocompatible and hazardous materials to provide a quantitative risk assessment.
RISK RATING
PANBioRA will develop a risk rating system that will display the suitability of the tested biomaterial.
PROJECT NEWS
Learn more about adverse immune responses to implantable biomedical devices in the latest journal article released by PANBioRA partner Protip.
PANBioRA partner SARTIK actively participated in the International Conferences of Serbian Society of Mechanics held in Sremski Karlovci, Serbia from 24-26 June.
From 3-5 June the PANBioRA consortium meets in Brussesl to present their research activities performed during the first 18 months of the project.
image credits: www.elveflow.com
Upcoming Events
in LA, USA
7th annual workshop on “Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications”
in Tampere, Finlannd
NoOC symposium is to bring together leading scientists and research groups of organ on chip -research field across Nordic countries.
in Nantes, France
2 day workshop focusing on bioprinting in cancer research
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