Components of the PANBioRa biomaterial risk assessment system

ANTIBODY TESTING
Patient-specific interactions between biomaterials and the immune system will be assessed using the ground-breaking Mimotope Variation Analysis technology.
ANTIBODY TESTING
BIOMATERIAL TESTING
Biochemical responses of cells to the presence of biomaterials will be monitored in real time and by integrated biosensors. In addition, PANBioRA includes cytotoxicity and genotoxicity tests with microscopic real-time monitoring capacities
BIOMATERIAL TESTING
CELL TESTING
Real-time electrochemical sensing will be used to determine the cellular response to a given biomaterial. A set of cytokines released to the extracellular environment will be used as biomarkers to assess the cell response to different biomaterials.
CELL TESTING
ORGAN ON A CHIP
Respiratory epithelium, gut and liver tissues will be miniaturized into organoids on chip to allow the determination of possible systemic and target organ-specific effects in both healthy and disease conditions.
ORGAN ON A CHIP
SIMULATIONS
SIMULATIONS
Potential risks that are difficult to assess experimentally – such as explosion hazards or full-scale biomaterial/microbiota interactions - will be covered by simulations developed within the project.
Data Analysis
DATA ANALYSIS
The readouts of the modules will be fed into a model developed within PANBioRA using known biocompatible and hazardous materials to provide a quantitative risk assessment.
RISK RATING
RISK RATING
PANBioRA will develop a risk rating system that will display the suitability of the tested biomaterial.

PROJECT NEWS

How to Predict Adverse Immune Reactions to Implantable Biomaterials?

Ever wondered what exactly the EU-funded project PANBioRA is aiming at? Check out the latest issue of the European Journal of Immunology!

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A Foreign Body Response‐on‐a‐Chip Platform

The latest PANBioRA scientific publication focuses on understanding the foreign body response (FBR) and desiging strategies to modulate such a response.

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New Research Topic related to 3D printing!

Is your research areas in the field of 3D printing of personalized medical implants (metals, ceramics and polymers) or medical devices? Submit your article until 15 April

 

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image credits: www.elveflow.com

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