Components of the PANBioRa biomaterial risk assessment system

ANTIBODY TESTING
Patient-specific interactions between biomaterials and the immune system will be assessed using the ground-breaking Mimotope Variation Analysis technology.
ANTIBODY TESTING
BIOMATERIAL TESTING
Biochemical responses of cells to the presence of biomaterials will be monitored in real time and by integrated biosensors. In addition, PANBioRA includes cytotoxicity and genotoxicity tests with microscopic real-time monitoring capacities
BIOMATERIAL TESTING
CELL TESTING
Real-time electrochemical sensing will be used to determine the cellular response to a given biomaterial. A set of cytokines released to the extracellular environment will be used as biomarkers to assess the cell response to different biomaterials.
CELL TESTING
ORGAN ON A CHIP
Respiratory epithelium, gut and liver tissues will be miniaturized into organoids on chip to allow the determination of possible systemic and target organ-specific effects in both healthy and disease conditions.
ORGAN ON A CHIP
SIMULATIONS
SIMULATIONS
Potential risks that are difficult to assess experimentally – such as explosion hazards or full-scale biomaterial/microbiota interactions - will be covered by simulations developed within the project.
Data Analysis
DATA ANALYSIS
The readouts of the modules will be fed into a model developed within PANBioRA using known biocompatible and hazardous materials to provide a quantitative risk assessment.
RISK RATING
RISK RATING
PANBioRA will develop a risk rating system that will display the suitability of the tested biomaterial.

PROJECT NEWS

PANBioRA partner interview!

Would you like to learn more about the PANBioRA partners and their motivation and challanges they are facing in the context of the project? Find out more in our newly launched series of PANBioRA...

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Successful PANBioRA partner meeting in Dublin

The PANBioRA consortium met in Dublin from 13-15th January for their Month 24 meeting. Besides fruitful discussions the presentation of the first version of the PANBioRA prototype was presented to all...

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E-Book on "Adverse Reactions to Biomaterials" available online

PANBioRA's scientific coordinator Nihal Engin Vrana has edited together with project partner Amir Ghaemmaghami a Frontiers Research topic on "Adverse Reactions to Biomaterials". Now an E-Book with all...

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image credits: www.elveflow.com

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