Today, biomaterial-based solutions play an important role in clinical applications.

They can be implemented e.g. astissue repair scaffolds or replace elements of damaged body parts. As these biomaterials directly interact with the human body, unforseen adverse reactions can occur.

PANBioRA will develop a tool to better assess a patient-specific immune reaction to biomaterials and thus allow improved clinical outcomes.

 

 

Components of the PANBioRa biomaterial risk assessment system

ANTIBODY TESTING
Patient-specific interactions between biomaterials and the immune system will be assessed using the ground-breaking Mimotope Variation Analysis technology.
ANTIBODY TESTING
BIOMATERIAL TESTING
Biochemical responses of cells to the presence of biomaterials will be monitored in real time and by integrated biosensors. In addition, PANBioRA includes cytotoxicity and genotoxicity tests with microscopic real-time monitoring capacities
BIOMATERIAL TESTING
CELL TESTING
Real-time electrochemical sensing will be used to determine the cellular response to a given biomaterial. A set of cytokines released to the extracellular environment will be used as biomarkers to assess the cell response to different biomaterials.
CELL TESTING
ORGAN ON A CHIP
Respiratory epithelium, gut and liver tissues will be miniaturized into organoids on chip to allow the determination of possible systemic and target organ-specific effects in both healthy and disease conditions.
ORGAN ON A CHIP
SIMULATIONS
SIMULATIONS
Potential risks that are difficult to assess experimentally – such as explosion hazards or full-scale biomaterial/microbiota interactions - will be covered by simulations developed within the project.
Data Analysis
DATA ANALYSIS
The readouts of the modules will be fed into a model developed within PANBioRA using known biocompatible and hazardous materials to provide a quantitative risk assessment.
RISK RATING
RISK RATING
PANBioRA will develop a risk rating system that will display the suitability of the tested biomaterial.

PROJECT NEWS

Due to a signifcant rise of coronavirus infections in Portugal the Organising Committee of ESB 2021 (5-9 September 2021) has taken the decision to move it to a fully virtual format.

Online article on PANBioRA available in EU Research Journal's summer edition!

PANBioRA's 7th press release gives an outlook on next activities in this last project year

image credits: www.elveflow.com

Upcoming Events

in Zurich, Switzerland (hybrid)

A hybrid event conference on science, technology and translation

in online

International Team for Implantology World Symposium 2021 held virtually

in online

The 31st Conference of the European Society for Biomaterials will be held virtually from September 5-9 2021.

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