Scientific Publications

Systematic overview of the research fields biomaterials and tissue regeneration! Edited by PANBioRA's scientific coordinator and other project partners - available now!

Biomaterials for Organ and Tissue Regeneration. New Technologies and Future Prospects, Nihal Vrana Helena Knopf-Marques Julien Barthes, Elsevier, 19 March 2020.



Basement membrane properties and their recapitulation in organ-on-chip applications, GolestanSalimbeigi, Nihal E.VranaAmir M.Ghaemmaghami, Pinar Y.Huri, Garrett B.McGuinnessin: Materials Today Bio, Vol. 15, June 2022. Open Access. Full text available here.


Compact Microfluidic Platform with LED Light-Actuated Valves for Enzyme-Linked Immunosorbent Assay AutomationMireia Burdó-Masferrer, María Díaz-González, Ana Sanchis, Álvaro Calleja, María-Pilar Marco, César Fernández-Sánchez, Antonio Baldi, in: Biosensors 2022, 12 (5), 280, 27 April 2022. Open Access. Full text available here.


Polyarginine as a Simultaneous Antimicrobial, Immunomodulatory, and miRNA Delivery Agent within Polyanionic HydrogelVarvara Gribova, Lauriane Petit, Leyla Kocgozlu, Cendrine Seguin, Sylvie Fournel, Antoine Kichler, Nihal Engin Vrana, Philippe Lavalle, in: Macromolecular Bioscience 22,4 (April 2022), 25 March 2022.


Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal diseaseMariliis Jaago, Nadežda Pupina, Annika Rähni, Arno Pihlak, Helle Sadam, Nihal Engin Vrana, Juha Sinisalo, Pirkko Pussinen & Kaia Palm, in: Communications Biology 5,205 (2022), 4 March 2022. Open Access. Full text available here.


From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architecturesNihal Engin Vrana, Sharda Gupta, Kunal Mitra, Albert A. Rizvanov, Valeriya V. Solovyeva, Ezgi Antmen, Majid Salehi, Arian Ehterami, Lea Pourchet, Julien Barthes, Christophe A. Marquette, Magnus von Unge, Chi-Yun Wang, Po-Liang Lai & Arindam Bit, in: Cell and Tissue Banking (2022), 9 January 2022.



Characterization of the Impact of Classical Cell-culture Media on the Response of Electrochemical SensorsAyman Chmayssem, Lauriane Petit, Nicolas Verplanck, Véronique Mourier, Séverine Vignoud, Nihal Engin Vrana, Pascal Mailley, in: Electroanalysis 1/2022, 24 December 2021.


Prediction of coating thickness for polyelectrolyte multilayers via machine learningVarvara Gribova, Anastasiia Navalikhina, Oleksandr Lysenko, Cynthia Calligaro, Eloïse Lebaudy, Lucie Deiber, Bernard Senger, Philippe Lavalle & Nihal Engin Vrana, in: Scientific Reports, Vol. 1 No. 1, 21 September 2021. Open Access. Full text available here.


An In-Silico Corrosion Model for Biomedical Applications for Coupling With In-Vitro Biocompatibility Tests for Estimation of Long-Term EffectsTijana Šušteršič, Gorkem Muttalip Simsek, Guney Guven Yapici, Milica Nikolić, Radun Vulović, Nenad Filipovic and Nihal Engin Vrana, in: Front. Bioeng. Biotechnol. 9:718026., 7 September 2021. Open Access. Full text available here.


Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield MicroscopyUka A.Ndreu Halili A.Polisi X.Topal A.O.Imeraj G.Vrana N.E., in: Cells Tissues Organs, 29 June 2021.


Biomechanical and functional comparison of moulded and 3D printed medical siliconesAlexandra ZühlkeMichael GasikNihal Engin VranaCeline Blandine MullerJulien BarthesYevgen BilotskyEdwin CourtialChristophe Marquette, in: Journal of the Mechanical Behavior of Biomedical Materials, 16 June 2021.


Reversed-engineered human alveolar lung-on-a-chip modelDi Huang, Tingting Liu, Junlong Liao, Sushila Maharjan, Xin Xie, Montserrat Pérez, Ingrid Anaya, Shiwei Wang, Alan Tirado Mayer, Zhixin Kang, Weijia Kong, Valerio Luca Mainardi, Carlos Ezio Garciamendez-Mijares, Germán García Martínez, Matteo Moretti, Weijia Zhang, Zhongze Gu, Amir M. Ghaemmaghami, Yu Shrike Zhang, in: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 11 May 2021. Open Access. Full text available here.


Mitigating the foreign body response through 'immune-instructive' biomaterials, Lisa Kämmerling, Leanne Fisher, Ezgi Antmen, Gorkem Muttalip Simsek, Hassan Rostam, Nihal E. Vrana, Amir M. Ghaemmaghami, in: Journal of Immunology and Regenerative Medicine, May 2021.


PVA/gelatin-based hydrogel coating of nickel-titanium alloy for improved tissue-implant interfaceG. M. Simsek, J. Barthes, C. Muller, G. B. McGuinness, N. E. Vrana, G. G. Yapici, in: Applied Physics A. Materials Science & Processing, Volume 127, Issue 7, 28 April 2021.


Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites, Ayman Chmayssem, Nicolas Verplanck, Constantin Edi Tanase, Guillaume Costa, Karen Monsalve-Grijalba, Simon Amigues, Mélanie Alias, Maxime Gougis, Véronique Mourier, Séverine Vignoud, Amir M. Ghaemmaghami, Pascal Mailley, in: Talanta (2021), 15 March 2021.


Reference method for off-line analysis of nitrogen oxides in cell culture media by an ozone-based chemiluminescence detector, Ayman Chmayssem, Karen Monsalve-Grijalba, Mélanie Alias, Véronique Mourier, Séverine Vignoud, Loïc Scomazzon, Céline Muller, Julien Barthes, Nihal Engin Vrana, Pascal Mailley, in: Analytical and Bioanalytical Chemistry (2021), 6 January 2021.


Biofunctionalization of 3D-printed silicone implants with immunomodulatory hydrogels for controlling the innate immune response: An in vivo model of tracheal defect repair, J.Barthes, P.Lagarrigue, V.Riabov, G.Lutzweiler, J.Kirsch, C.Muller, E.-J.Courtial, C.Marquette, F.Projetti, J.Kzhyskowska, P.Lavalle, N.E.Vrana, A.Dupret-Bories, in: Biomaterials, Volume 268, January 2021.



Improving the colonization and functions of Wharton's Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogelG. Lutzweiler, J. Barthes, A.L. Charles, V. Ball, B. Louis, B. Geny and N. E. Vrana, in: Biomedical Materials, Vol. 16 No. 1, 26 November 2020.


Chapter 4 - Lung on a chip and epithelial lung cells modeling, Milica Nikolic, Nenad Filipovic, in: Computational Modeling in Bioengineering and Bioinformatics, 2020, pp.105-135.


Effect of Preprocessing on Performance of Neural Networks for Microscopy Image Classification, Arban Uka, Xhoena Polisi, Julien Barthes, Albana Ndreu Halili, Florenc Skuka, Nihal Engin Vrana, in: 2020 International Conference on Computing, Electronics & Communications Engineering (iCCECE), 23 October 2020.


Recent Advances in Antiinflammatory Material Design, Eloïse Lebaudy, Sylvie Fournel, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova, in: Advanced Healthcare Materials, 9 (19), 13 October 2020.


New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?, Lorène Tallet, Varvara Gribova, Lydie Ploux, Nihal Engin Vrana, Philippe Lavalle, in: Advanced Healthcare Materials, 9 (19), 12 October 2020.


Polyarginine Decorated Polydopamine Nanoparticles with Antimicrobial Properties for Functionalization of Hydrogels, C.Muller, E.Berber, G.Lutzweiler, O.Ersen, M.Bahri, P.Lavalle, V.Ball, N.E.Vrana, J.Barthes, in: Front. Bioeng. Biotechnol.8: 982. Open Access.Full text available here.


Personalization of medical device interfaces: decreasing implant-related complications by modular coatings and immunoprofiling, N.E. Vrana, K.Palm, P. Lavalle, in: Future Science OA 2020. Open Access. Full text available here.


The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation, G.Lutzweiler, A. Ndreu Halili, N.E.Vrana, in: Pharmaceutics 2020, 12, 602. Open Access. Full text available here


Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo, Hassan M.Rostam, Leanne E.Fisher, Andrew L.Hook, Laurence Burroughs, Jeni C. Luckett, Grazziela P. Figueredo, Chidimma Mbadugha, Alvin.K.Teo, Arsalan Latif, Lisa Kämmerling, Mitchell Day, Karen Lawler, David Barrett, Somaia Elsheikh, Mohammad, Ilyas, David A.Winkler, Morgan R. Alexander, Amir M.Ghaemmaghami , in Matter, 01 May 2020, Open Access. Full text available here.


Metabolic characterisation of THP-1 macrophage polarisation using LC–MS-based metabolite profiling, Alaa Abuawad, Chidimma Mbadugha, Amir M. Ghaemmaghami, Dong-Hyun Kim, in: Metabolomics 16/33 (29 February 2020). Open Access, Full text available here.


Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity, Varvara Gribova, Fouzia Boulmedais, Agnès Dupret-Bories, Cynthia Calligaro, Bernard Senger, Nihal Engin Vrana, Philippe Lavalle, in: ACS Appl. Mater. Interfaces 2020 .


Adjustment of Cell Adhesion on Polyurethane Structures via Control of the Hard/Soft Segment Ratio, Gaëtan Lutzweiler, Julien Barthes, Nihal Engin Vrana, Michel Rawiso, Benoît Louis, Josselin Mayingi, Albane Carre, Wiebke Drenckhan, Pierre Schaaf, in: Macromolecular Materials and Engineering, 20 March 2020.


Controlling porous titanium/soft tissue interactions with an innovative surface chemical treatment, Responses of macrophages and fibroblasts, Julien Barthes. Martina Cazzola, Celine Muller, Camille Dollinger, Christian Debry, Sara Ferraris, Silvia Spriano, Nihal E.Vrana, in: Materials Science and Engineering: C, 13 March 2020.


Validation of Milner’s visco-elastic theory of sintering for the generation of porous polymers with finely tuned morphology, G. Lutzweiler, J. Farago, E. Oliveira, L. Jacomine, O. Erverdi, N.E. Vrana, A Testouri, P Schaaf, W. Drenckhan, RSC Soft Matter, 06 January 2020.



Dual Growth Factor Delivery with PLGA Nanoparticles in Silk Fibroin/PEGDMA Hydrogels for Articular Cartilage Tissue Engineering, M. Fathi-Achachelouei, D. Keskin, E. Bat, N.E. Vrana*, Aysen Tezcaner, Journal of Biomedical Material Research Part B: Applied Materials, Wiley, 24 December 2019.


Using 3D Printing and Bioprinting Technologies for Personalized Implants, Barthes, E.J. Courtial, E. Brenet, C.B. Muller, H. Knopf-Marques, C. Marquette, N.E. Vrana, Chapter in Advances in Biomechanics and Tissue Regeneration, ed. M.H. Doweidar, Elsevier publishing, 2019, p.269-286.


A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell‐derived epithelial tissue patches, Pramod Kumar Sait Ciftci Julien Barthes Helena Knopf‐Marques Céline Blandine Muller Christian Debry Nihal E. Vrana Amir M. Ghaemmaghami, Journal of Tissue Engineering and Regenerative Medicine, Volume 13, Issue 12, December 2019.


The effect of healing phenotype-inducing cytokine formulations within soft hydrogels on encapsulated monocytes and incoming immune cells, Ivana Ščigalková, Julie Bystroňová,  Lenka Kovářová, Martin Pravda, Vladimír Velebný,  Vladimir Riabov,  Harald Klüter, Julia Kzhyshkowsk  and  Nihal Engin Vrana, RSC Advances, Issue 37, 10 July 2019. Full text available here


Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine), HelenaKnopf-Marques, JulienBarthes, SarahLachaalb, AngelaMutschler, CélineMuller, Florent Dufour, Morgane Rabineau, Edwin-Joffrey Courtial, Julie Bystroňová, Christophe Marquette, Philippe Lavalle, Nihal Engin Vrana, Materials Science and Engineering: C, Volume 104, avialable online 19 June 2019.


Use of Nanoparticles in Tissue Engineering and Regenerative Medicine, Milad Fathi-Achachelouei, Helena Knopf-Marques, Cristiane Evelise Ribeiro da Silva, Julien Barthès, Erhan Bat, Aysen Tezcaner and Nihal Engin Vrana,Front. Bioeng. Biotechnol., 24 May 2019, Open Access, Full text available here.


Modulation of Cellular Colonization of Porous Polyurethane scaffolds via the control of pore interconnection size and nanoscale surface modifications,  G. Lutzweiler, J. Barthes, G. Koenig, H. Kerdjoudj, J. Mayingi, F. Boulmedais, P. Schaaf, W. Drenckhan,and N. E. Vrana, , ACS Appl. Mater. Interfaces 2019, 10 May 2019.


How to Predict Adverse Immune Reactions to Implantable Biomaterials?, M.Ungemach, T.Doll, N.E. Vrana, European Journal of Immunology, 2019. 49: p.517–520, Full text available here.


A Foreign Body Response‐on‐a‐Chip Platform, Fatemeh Sharifi, Su Su Htwe, Martina Righi, Hua Liu, Anna Pietralunga, Ozlem Yesil‐Celiktas, Sushila Maharjan, Byung‐Hyun Cha, Su Ryon Shin, Mehmet Remzi Dokmeci, Nihal Engin Vrana, Amir M. Ghaemmaghami, Ali Khademhosseini, Yu Shrike Zhang, in: Advanced Healthcare Materials, Volume 8, Issue 4, 29 January 2019.


Editorial: Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and in vitro Models for Biomaterial Testing, Nihal Engin Vrana, Amir M. Ghaemmaghami and Pinar Zorlutuna, in:  Front. Bioeng. Biotechnol., 11 February 2019, Open Access, full text available here.


Spectroscopic and theoretical investigation of the potential anti-tumor and anti-microbial agent, 3-(1-((2-hydroxyphenyl)amino)ethylidene)chroman-2,4-dione, Edina H. Avdović, Dušan S. Dimić, Jamina M. Dimitrić Marković, Nenad Vuković, Milanka Đ.Radulović, Marko N.Živanović, Nenad D.Filipović, Jelena R.Đorović,  Srećko R.Trifunović, Zoran S.Marković, in: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 206, 5 January 2019.


Computational Analysis of Hip Implant SurfacesA. Vulović, N. Filipović, in: Journal of the Serbian Society for Computational Mechanics, Vol. 13 / No. 1, 2019, pp 109-119.



Mathematical Modelling of Polymer Trajectory during Electrospinning, I. Ferouka, T. Šušteršič, M. Živanović, N. Filipović, Jorunal of the Serbian Society for Computational Mechanics, Vol 12, Number 2 2018. Open Access, Full text available here.


The importance of controlled mismatch of biomechanical compliances of implantable scaffolds and native tissue for articular cartilage regeneration, Michael Gasik, Alexandra Zühlke, Anne-Marie Haaparanta, Virpi Muhonen, Kaisa Laine, Yevgen Bilotsky, Minna Kellomäki and Ilkka Kiviranta, Frontiers in Bioengineering and Biotechnology, 16 November 2018, Open Access, Full text available here.


Numerical simulation of electrospinning process in commercial and in-house software PAK, Tijana Šušteršič, Liliana Liverani,, Aldo R Boccaccini, Slobodan Savić, Aco Janićijević and Nenad Filipović, Materials Research Express, Volume 6, Number 2, 07 November 2018.


Biomaterials and Immune Response Complications, Mechanisms and Immunomodulation, Nihal Engin Vrana, CRC Press , 07 September 2018.


Immune assisted tissue engineering via incorporation of macrophages in cell-laden hydrogels under cytokine stimulation
Julien G. Barthès, Camille Dollinger, Celine B. Muller, Urmas Liivas, Agnes Dupret-Bories, Helena Knopf-Marques and Nihal E. Vrana, in Frontiers in Bioengineering and Biotechnology, 13 July 2018, Open Access, Full text available here.

Enabling personalized implant and controllable biosystem development through 3Dprinting, N. Nagarajan
A. Dupret-Bories, Erdem Karabulut, P.Zorlutuna, N.E.Vrana, Biotechnology Advances, first available online 9 February 2018

Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression
Arso M. Vukicevic, Gordana R. Jovicic, Milos N. Jovicic, Vladimir L. Milicevic & Nenad D. Filipovic, in: Computer Methods in Biomechanics and Biomedical Engineering Volume 21, 2018 - Issue 2, pp.169-176.